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Monday December 17, 2007
Human Growth Hormone |
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| Human Growth Hormone
NOTICE: This information is for entertainment purposes ONLY!
Full profiles on each individual steroid are here.
Pharmaceutical Name: Somatotrophin
Effective dose: 6-12 IU/day in combination with androgens and insulin for muscle growth, 3-6 IU/day for fat loss purposes
Average Street-price: $50 for 4 IU
Available Doses: 2,3,4,10,12,16,24,72 IU vials for subcutaneous injection
Brands & Products:
Biomed Somatohorm (PL) 4 IU
Ferring Zomacton (G) 4 and 12 IU
Kabi Pharmacia Genotr (NO) 2,3 and 4 IU
Genetonorm (B,ES, PT) 4 IU
Genotropin (S,BG,A,GR,NL) 2 and 3 IU
Genotropin (S,DK,PT,CZ,NO,CH) 12 IU
Genotropin (G,DK,FI,S,A,PT,HU,GR,NL,CH) 16 IU
Geno Kabi Quick (G) 2 and 3 IU
Somatohorm (CZ,ES,FR) 4 IU
Genentech Nutropin (US) 10 mg solution
Nutropin Aqua (US) 10 mg solution
Protropin (US, MX) 10 mg solution
Lilly Humatrope (G,DK,ES,S,GB,FI,B, HU,GR,CZ,NO,NL,I,CH) 4 IU
Humatrope (US,MX) 5 mg solution
Humatrope (G,DK,ES,GB,FI,NL,NO,GR,CH) 16 IU
Humatrope (ES) 72 IU
Novo / Nordisk Norditropin (PL,DK,A,ES,I,NO,HU,BG,MX) 4 IU
Norditropin (G,FI,HU,DK,B,PL,CH,GB, NO,ES,NL,BG,CZ,MX,GR) 12 IU
Norditropin (CZ,HU,FI,GR,NO,A,ES,DK,NL) 24 IU
Norditropin Pen Set (G) 24 IU
Pharma Genotropin (MX) 4 IU
Russian (unknown) Somatotropin (Russia) 4 IU
Serono Saizen (G,CH,ES) 2 IU
Saizen (G,A,CH,ES,I,GB,GR, FI,HU,FR,S,CZ,MX) 4 IU
Saizen (S,FI,GB,CH,CZ,HU,FR,ES,MX) 10 IU
Serostim (US) 4, 5 or 6 mg
Characteristics:
HGH is, unlike most hormones used by bodybuilders, not a steroid hormone, but a proteinaceous hormone made up of a chain of 191 amino acids. All animals have growth hormone, but each seems to be specific to the species. HGH was first isolated in the late 70's and early 80's as a biological form. The hormone was literally extracted from the pituitary of deceased individuals. As with anything extracted from carcasses this imposed a serious risk of contracting the Kreutzfeld-Jacob disease (since the late 90's best known as mad cow disease), a normally rare neural infliction that makes you spastic and can cause death over a period of no more than two weeks. Not exactly appealing. There also wasn't, understandably, much demand for such a compound on the black market. Late 80's early 90's geneticists succeeded in manufacturing a genetic form of HGH however, through a very complicated technique using mice genes and what have you not (I'm not a geneticist, don't ask me). This also seriously upped the price of the compound.
But around that time, mainly due to this safer form, some top-level athletes were taking an interest. With increasing drug tests making the most effective anabolics forbidden territory, a pharmaceutical race to find replacement compounds that could not be detected had begun. And since then several athletes have and are still using HGH. It's a very mythical compound, since professionals will use it in high doses and make obvious improvements, yet most recreational users seeking to try it have to settle for lower doses and get little if anything out of it in terms of lean muscle mass increases. Along with several human studies1,2 that clearly document that HGH administration offers us no benefit in this aspect, it makes one wonder. Its terribly expensive and most people seem to get nothing out of it. So is it really worth it when extremely effective steroids can be bought for the proverbial nickel and dime? I don't think so, but I'll get back to that later.
So what is GH useful for? Well first of all its effects on reducing body-fat have been well-documented. Daily doses of 3 to 6 IU injected subcutaneous have actually been shown to spot reduce body-fat mass and have, at least for some athletes, proven invaluable in contest preparation time. This dose, for short periods of time, may be somewhat affordable to a truly dedicated athlete. But one can still wonder if it is really worth it. GH has also been shown to elicit extremely positive effects on erythropoeisis3, the manufacture of red blood cells. The administration of GH in older athletes with a strong decline in GH levels has shown a severe improvement in endurance. Since levels of GH decline by half every decade, a person of 60 has roughly 15-20% of the GH he had at age twenty. So HGH is especially beneficial to older athletes regarding the effects on endurance. But just how effective superdosing HGH in younger top athletes is, no one really knows. It would be virtually undetectable as well, so no doubt this has been experimented with.
Now in regards to muscle mass, I've yet to see anything prove the contrary of what the studies I provided claimed. I've not seen HGH increase muscle mass at all. Then again, I've never seen anyone use 10-12 IU per day the way some top level professionals do. Some claim that HGH can cause hyperplasia rather than hypertrophy. Hypertrophy is the growth of muscle cells, hyperplasia is the division and thus multiplication of cells. The theory goes that this does not increase size immediately, but in due time, due to the increase in the amount of cells, when they all do hypertrophy under the influence of steroids and insulin, the result will be much greater. Of course one side-effects of HGH is that it seems to increase the size of everything, including bones (which gives very ugly protrusions in people who have no growth left in them) and intestines (which explains the incredible increase in gut size of professional bodybuilders, despite low body-fat percentages). Now these side-effects alone would allow for several pounds increase. Stack that with 3 grams per week of testosterone and an equal dose of other steroids, some insulin, lots of rest and 8000 calorie diets, and I really don't see how much the HGH contributed in creating the muscle-weight these athletes have. I mean amateur and recreational users top 260 pounds, fairly lean using 1 gram of test and 1 gram of other drugs per week, maybe some insulin. It seems to me at least that HGH is a royal waste of money. Even if it did contribute 3 or 4 pounds, is it worth a habit of 150 dollars per day? Not in my book.
In short, HGH may provide many benefits, but will rarely be worth the money. Top-level competitors, especially those subject to drug tests may find this to be worth it to give themselves and edge, most will not. HGH is a very effective compound with a lot to offer, but currently not really worth the money you'd pay for it. It is getting cheaper (In Europe the popular thing now is the 36 IU Genetonorm, selling for 50-60 bucks) but until manufacturing becomes more cost-effective, chances of prices reaching sane levels any time soon are not that high. What has been an interesting observation is the re-appearance of the old biological form. While all commercial forms had been discontinued, underground versions of the biological form have resurfaced. Previously despised, the chants of the top competitors claiming HGH is the holy grail of performance, many amateurs will now risk using this crude version to get some of that benefit for a cheaper price. Even if it means they have a high chance of dieing one of the most terrible deaths known to man. It's a funny world, eh?
Stacking and Use:
For the best results HGH should be stacked with any number of compounds. If at all possible the use of a serious steroid cycle, cytomel (T3) and insulin should be used. Not only do these promote the best results with HGH, HGH will allow for better results with them. It promotes the release if IGF-1 (insulin-like growth factor I) in the liver, which is an extremely anabolic hormone. In conjunction with insulin it will therefore promote extreme nutrient retention in the muscle cells, providing the perfect anabolic environment. Cytomel seems to give it a great deal to work with. Metabolism is increased, together they form a great fat-loss combo, but more nutrients now become available as well. Along with the nitrogen/protein retention of some strong anabolic steroids this should provide very good overall results. But one can't mistake HGH as some form of miracle cure. Its no better than these other compounds, and it won't turn the cycle into a miracle of muscle growth either. Some would think this because of the incredible cost, but nothing of the sort is true. It has equal use, it just costs a hell of a lot more. Which is my main reason in stating its simply not worth what you get out of it.
For all intents and purposes of increasing endurance and performance to some level, 3 to 6 IU will suffice. The same for most fat loss purposes. HGH has a very short half-life (30-45 minutes or so) and should be injected at least once daily, maybe twice daily if at all possible. For possibly more anabolic results due to its effects on freeing nutrients and increasing IGF-1 levels, 10-12 IU per day are needed for an extended period of time (10-15 weeks), usually in conjunction with other anabolic compounds. Its interesting to note that in your choice of anabolic, an aromatizing compound like testosterone should be given preference since estrogen has positive benefits on HGH as well.
References
1 Deyssig R, Frisch H, Blum WF, Waldhor T. Effect of growth hormone treatment on hormonal parameters, body composition and strength in athletes., Acta Endocrinol (Copenh) 1993 Apr;128(4):313-8
2 Growth hormone effects on metabolism, body composition, muscle mass, and strength. Yarasheski KE., Exerc Sport Sci Rev 1994;22:285-312
3 Christ ER, Cummings MH, Westwood NB, Sawyer BM, Pearson TC, Sonksen PH, Russell-Jones DL. The importance of growth hormone in the regulation of erythropoiesis, red cell mass, and plasma volume in adults with growth hormone deficiency., J Clin Endocrinol Metab 1997 Sep;82(9):2985-90
Back To The Main Steroid Profiles Page
GROWTH HORMONE (GH, HGH, Genotropin)
Generic Name: Somatotropin
The use of exogenous sources of Growth Hormone has been popular in the United States for almost 8 years now. Originally, athletes used biologically active forms that were the actual extract of the pituitary glands of cadavers. While production was under way on the synthetic, recombinant DNA versions of this drug, it was discovered that the biologically active form was associated with the formation of a rare brain virus called Creutzveldt Jacob Disease. This was a fatal virus that afflicted a very small number of GH users, none of whom were athletes. In light of this discovery, the FDA removed all of these natural GH versions from the market in the United States. Luckily, the synthetic recombinant versions were approved by the FDA a short time afterwards. These versions were developed after years of experiments with amino acid chains. The first of these versions was patented and produced by Genentech Labs with the brand name Protropin. A short time later, another form of synthetic Growth Hormone gained FDA approval. It was produced by Eli Lilly Labs and brand named Humatrope. This product was allowed to be patented because it was shown to be unique in that it contained a slightly different amino acid chain than the Protropin. The difference was that Humatrope had 191 amino acid chains in sequence and Protropin had 192. For some very complicated reasons, the 191 amino acid configuration has been shown to be more effective. It had been speculated that these synthetic versions of GH would greatly improve the cost effectiveness of using GH, yet that has not been the case. An athlete who wants to do a cycle of GH can still expect to be out as much as $2000 a month. There are numerous versions of Growth Hormone available in Europe, the majority of which are made up of the 191 amino acid sequence. There is even a form of the original human extract Growth Hormone, called Grorm which is available in a few countries. Although this drug is indicated for the treatment of pituitary deficient dwarfism, it has been used extensively by athletes who are attempting to alter their body composition. Growth Hormone itself, is an endogenous hormone produced by the pituitary gland. It exists at especially high levels during the teen years when it promotes growth of almost all tissues. It also contributes to the deposition of protein and promotes the breakdown of fat for use as energy. As the body reaches full maturation, the endogenous levels of GH are substantially diminished. After this, GH is still present in the body but at a substantially lower level where it continues to aid in protein synthesis, RNA and DNA reactions and the conversion of body fat to energy. By introducing an exogenous source of this hormone, athletes are hoping to promote these effects, causing the body to deposit more muscle tissue while at
the same time reducing body fat stores. On paper, GH should work exceptionally well; however, it does not seem to be delivering up to its potential. Most athletes who have experimented with this product end up being disappointed. There is some evidence that exogenous sources of GH are being destroyed by antibodies which appear after the introduction of the synthetic compound. Although the 191 amino acid sequence versions have been shown to produce less of an antibody reaction, they are still not yielding consistent results. I have speculated as to whether the introduction of exogenous GH would yield an appreciable degree of efficacy simply due to the fact that the body does not have sufficient receptor affinity to GH in the post-teen years. A number of athletes claim that GH is not that effective on its own, but in a stack with steroids it can do remarkable things. Perhaps there is some type of actual synergism created by the concomitant use of these two agents. Empirical data suggests that the efficacy of GH is dose related and that the majority of users may not have been taking enough of it to get positive results. Despite speculation concerning its efficacy, synthetic GH is being used by thousands of elite athletes. These include men and women bodybuilders, strength athletes, as well as a multitude of Olympic competitors. Although Growth Hormone is banned by athletic committees, there is no method for the detection of it which allows drug tested competitors to use this product freely without any ramifications. Adverse reactions to GH use are rare but technically could involve
acromegaly (elongation of the feet, forehead and hands). Other possible side effects involve overgrowth of the elbows or jaw, thickening of the skin and a type of diabetes. Effective dosages seem to be in the area of 4 IU/day. Cycle length is usually determined by how long the athlete can afford it. Some take the product for 6 week cycles, others use it year round.
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